Insuline resistentie: alles wat je moet weten

Insulin resistance: everything you need to know

Geschreven door: Mirjam

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Leesduur: 8 min

Many people are concerned about insulin resistance, and that's no wonder, as it's becoming increasingly common. The number of people with insulin resistance has increased dramatically in recent decades.

If you have a form of insulin resistance, your body responds less effectively (or not at all) to the hormone insulin. Insulin's role includes keeping blood sugar levels stable. If you'd like to learn more about the causes of insulin resistance, its symptoms and dangers, and how to prevent it, read on.

Insulin resistance is caused by excess weight, inactivity, stress, and poor diet. Symptoms include fatigue, hunger, weight gain, and high blood pressure.

Untreated insulin resistance increases the risk of diabetes, cardiovascular disease, fatty liver disease and cognitive decline, and affects hormonal balance.

A healthy diet, strength training, less sugar and alcohol, stress management, and sufficient sleep improve insulin sensitivity and prevent further complications.

Insulin and its role in the body

Insulin plays a key role in absorbing energy from food. Carbohydrates are broken down into glucose and ultimately absorbed into your bloodstream. The more carbohydrates you eat and the more easily they are absorbed, the higher your blood sugar levels.

Insulin (produced in the pancreas) then ensures that this sugar can be absorbed into the cells, so it can be used for energy. In this way, insulin also ensures that your blood sugar level doesn't get too high.

Furthermore, insulin promotes the storage of excess glucose in the form of glycogen in the liver and muscles. The hormone thus plays a crucial role in metabolism and helps determine how effectively our body can utilize the energy from the food we eat.

If you have a form of insulin resistance, your body's cells respond less effectively to insulin. This makes it difficult for you to regulate your blood sugar levels. You can become more resistant to insulin for various reasons.

Causes of insulin resistance

There are several causes for the development of insulin resistance. On the one hand, it can be genetic (you simply have a predisposition), but lifestyle and dietary habits also play a significant role.

1. Overweight and obesity

People who are overweight, especially around the abdominal area, are more likely to suffer from insulin resistance. Fat cells in the abdomen release substances that promote inflammatory processes in the body, which can disrupt insulin sensitivity. These inflammatory processes can reduce the effectiveness of insulin in cells.

2. Physical inactivity

Regular exercise helps muscles use insulin more effectively. Without regular exercise, muscles can become less sensitive to insulin, requiring more insulin to move glucose into the cells.

3. Unhealthy diet

A diet high in processed foods, saturated fats, and added sugars can promote insulin resistance. Such diets can lead to weight gain and inflammatory processes that reduce insulin sensitivity.

4. Chronic stress

Long-term stress can lead to hormonal changes that negatively impact insulin sensitivity. Elevated levels of cortisol, the "stress hormone," can impair insulin function in the body.

5. Lack of sleep

Not getting enough rest and sleep can reduce the body's insulin sensitivity. Lack of sleep can lead to hormonal imbalances that affect how the body uses insulin.

6. Use of medication

Certain medications, such as corticosteroids, can cause insulin resistance as a side effect. These medications can affect how insulin works in the body, potentially leading to elevated blood sugar levels.

7. Polycystic Ovary Syndrome (PCOS)

Women with PCOS often suffer from insulin resistance. Although the precise link between PCOS and insulin resistance isn't fully understood, it's thought that hormonal imbalance contributes to reduced insulin sensitivity.

8. Genetic factors

Family history and genetic predisposition can play a role in insulin resistance. Individuals with family members who have type 2 diabetes or insulin resistance may have an increased risk of developing it themselves. Good nutrition, sufficient sleep, and daily exercise are especially important in these cases.

Symptoms of insulin resistance

The early stages of diabetes often progress without any obvious symptoms. However, the underlying disease becomes increasingly severe. At some point, you will experience symptoms. These can vary from person to person. These are the symptoms that can occur with insulin resistance:

  • Weight gain - People with insulin resistance gain weight more easily.
  • Urinating more often - High blood sugar levels cause the kidneys to work harder to filter the extra glucose from the blood. This causes you to urinate more often.
  • Increased hunger - When your body is resistant to insulin, it interferes with the normal communication between your brain and insulin. This can lead to increased cravings, especially for sweets and carbohydrates.
  • Increased thirst - You become more thirsty because you lose a lot of fluid because you have to urinate more often.
  • Brain fog - Brain fog and problems with concentration are also common with this condition.
  • Fatigue - Due to fluctuating blood sugar levels and your body having trouble absorbing glucose, you may feel exhausted and tired.
  • High blood pressure - You are more likely to have high blood pressure if you are insulin resistant.
  • Skin changes - Insulin resistance often accompanies Acanathosis nigricans, which causes dark patches to appear on the skin.
  • Recurrent infections - The precursor to diabetes causes reduced resistance.
  • Irregular Menstruation - Insulin resistance causes disruptions in hormone levels, which can lead to irregular menstruation and fertility problems.

Dangers of undiscovered resistance

It's important to act quickly if you have insulin resistance. If left untreated, it can have a significant negative impact on your health. These are the dangers of undetected insulin resistance:

  • Type 2 Diabetes - When your body is resistant to insulin, you are in the early stages of type 2 diabetes. As insulin resistance worsens, the pancreas can no longer produce enough insulin, causing persistently high blood sugar levels. This ultimately leads to diabetes.
  • Non-alcoholic fatty liver disease - When you are insulin resistant, fat accumulates in the liver. This can lead to more serious conditions.
  • Sleep apnea - Sleep apnea and insulin resistance are linked, one condition can cause the other.
  • Cognitive Decline - Research suggests there may be a link between insulin resistance and cognitive decline.
  • Cardiovascular Disease - High blood sugar damages blood vessels and there is a direct link between insulin resistance and the risk of heart diseases such as heart attack, myocardial infarction and coronary heart disease [2] .
  • PCOS - People with PCOS have a higher risk of developing diabetes because the condition disrupts hormonal balance.
  • Neuropathy - Diabetes can damage the nerves, which can cause neuropathy.
  • Kidney disease - If you have reduced insulin resistance, you are at increased risk of developing chronic kidney disease. The disease can also lead to kidney damage.

Types of tests for insulin resistance

Fortunately, insulin resistance can be easily detected. This is done with clinical tests and laboratory research. The following tests are used:

  • Oral Glucose Tolerance Test: In this test, you are given a drink containing glucose and your blood sugar level is tested both before and after taking it.
  • Glucose Tolerance Test - This test requires an empty stomach. An elevated fasting blood sugar level can indicate insulin resistance.
  • Lipid profile - If you have low HDL cholesterol levels and abnormal lipid levels, this may indicate insulin resistance.
  • Glycated hemoglobin (Hb1Ac) - When these levels are high, you may have prediabetes or insulin resistance.
  • Insulin levels and HOMA-IR - This test measures blood glucose and insulin levels.
  • Other physical factors - This looks at other factors, such as inflammatory markers and liver and kidney function.

Reduce insulin resistance

If you are insulin resistant (or suspect you are), you can improve your symptoms by adjusting your lifestyle and diet. The goal is to control blood sugar fluctuations, ensure your cells become more sensitive to insulin, and prevent more serious health problems.

Make sure you choose a healthy and balanced diet. This will help you control your blood sugar levels and also help you lose excess weight.

Schedule regular exercise. Combine strength training with cardio for the best results. Exercise is also good for promoting weight loss. Maintaining a healthy weight is also an important factor in addressing insulin resistance.

It can also be helpful to monitor your blood sugar levels. This gives you insight into how your body responds to changes in your diet and lifestyle. It's also important to treat underlying conditions, such as PCOS, as these can influence insulin resistance.

Preventing insulin resistance

As you've read, insulin resistance can lead to serious health problems. Ultimately, prevention is better than cure. Insulin resistance can be prevented by a healthy lifestyle. Below, you can read what to look out for.

1. Exercise more

Regular exercise is a good way to improve your cells' insulin sensitivity. It's also true that when you exercise, your muscles absorb more glucose. Therefore, it's recommended to exercise every day.

In principle, any form of exercise is good, but strength training, in particular, has many positive effects on insulin resistance. Try to train with weights, such as dumbbells, or resistance training two or three times a week.

By exercising (intensively), your cells use up glucose. Your cells therefore want to absorb more glucose from your blood, which automatically makes them more sensitive to insulin.

2. Limit sugar intake

Food, especially sugar, has a significant impact on your blood sugar levels. To prevent insulin resistance, it's important to limit your refined sugar intake as much as possible. If you enjoy sweets, avoid buying candy and other snacks and only eat them on special occasions. Choose sugar-free and healthy snacks, such as vegetable snacks, a cracker with cheese, or nuts.

3. Moderate alcohol consumption (preferably avoided)

Alcohol also has a significant impact on blood sugar levels, as it disrupts them. When you drink, it immediately causes a rise in blood sugar levels [3] . This is because drinks contain a lot of carbohydrates and sugars, especially mixed drinks. To reduce the risk of insulin resistance, it's best to limit your alcohol consumption.

In addition, heavy alcohol consumption (more than six glasses per day) can even increase the risk of developing diabetes.

4. Limit stress

Another factor that plays a role in the development of insulin resistance is stress. Stress is associated with high levels of cortisol (the stress hormone). This hormone negatively impacts insulin function and can therefore contribute to insulin resistance.

You can't always avoid stress, but try to make sure you take time to relax every day. Make yourself more resilient to stress with a mindfulness or meditation course .

5. Sleep well

Finally, it's important to ensure a good night's sleep. When you sleep, insulin levels are regulated. Sleep also affects your cells' sensitivity to insulin. So, make sure you get enough sleep every night and address any sleep problems if necessary.

Mirjam Sprenger - Natural Performance

Miriam

Mirjam felt a connection with nature from a young age. This has led to a deep passion for health, natural remedies, and healthy eating. She also loves reading, yoga, and writing. When the weather is nice, she enjoys exploring new hiking trails.

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