De beste vitamine B12 tabletten kopen? Let op deze 4 punten

Buying the best vitamin B12 tablets? Pay attention to these 4 points.

Geschreven door: Ebrina van der Bijl

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Leesduur: 9 min

Vitamin B12 is one of the most popular supplements and for good reason.

More and more people are noticing the consequences of a B12 deficiency, such as fatigue, concentration problems or memory loss.

But how do you choose the best vitamin B12 tablets?

In this article I explain what you should pay attention to when choosing the right B12 supplements.

Choose B12 tablets with bioactive forms such as methylcobalamin and adenosylcobalamin, which are absorbed directly by the body and work more effectively.

Melting tablets are better absorbed because they are absorbed directly through the oral mucosa, which is particularly beneficial for intestinal problems.

Vitamin B6 and folic acid improve absorption, allowing B12 to be better utilised and contributing to a healthy nervous system and energy levels.

How to recognize the best B12 tablets

To find the best B12 tablets, I recommend you look for the following features:

  • Bioactive forms of vitamin B12 – methylcobalamin and adenosylcobalamin – are best absorbed
  • Melting tablet or sublingual tablet – for fast and effective absorption
  • Contains substances that improve absorption – such as the active form of vitamin B6
  • Natural fragrances, colours and flavours – for example Stevia instead of sugars

The top 3 best vitamin B12 melt tablets

#1. B12 Premium - Natural Performance

B12 Premium melt tablets from Natuurlijk Presteren contain the two best forms of vitamin B12. These are even more effective thanks to the added vitamins (the active form of folic acid and active B6). The strawberry flavor comes from real strawberries.

The benefits:

  • Contains the 2 best forms of B12 in an effective dosage: 1000 mcg per tablet (50% Methylcobalamin and 50% Adenosylcobalamin)
  • Contains the active forms of vitamin B6 (Pyridoxal 5-phosphate) and folic acid ( Quatrofolic® 5-MTHF Folate)
  • Pleasant strawberry flavour, made from natural strawberry aroma

Natuurlijk Presteren melt tablets earn the top spot because they contain the best forms of B12 and the beneficial vitamins B6 and folic acid. This ensures optimal effectiveness. The dosage is also ideal: effective and safe.

In addition, the natural strawberry flavour is very pleasant, which makes them suitable for children as well.

#2.B12 Combi 6000® - Vitakruid

Vitakruid's B12 combination melt tablets also contain the two easily absorbed forms of B12 and the active forms of B6 and folic acid to enhance their effectiveness. The strawberry flavor is derived from natural aromas.

The benefits:

  • Contains the easily absorbable forms of B12: Methylcobalamin (50%) and Adenosylcobalamin (50%)
  • Contains the active forms of vitamin B6 (Pyridoxal 5-phosphate) and folic acid ( Quatrofolic® 5-MTHF Folate)
  • Natural strawberry and lemon flavouring

The disadvantage

  • The dosage of B12 is very high: 6000 mcg per tablet

This product is available at bol.com, among others.

The B12 melt tablets from Vitakruid are similar to my number 1 from Natuurlijk Presteren, but contain 6000 mcg per tablet.

Because B12 is water-soluble, you pee out any excess, but your body must first process it. Such a high dose can be helpful for severe deficiencies, but is usually unnecessary.

#3. B12 lozenges - Vitals

Vitals B12 melt tablets provide an effective and safe dose of methylcobalamin, but without the fortifying B6 and folic acid. The cherry flavor of these tablets is striking (most B12 tablets taste like strawberry).

The benefits:

  • Contains methylcobalamin in an effective and safe dosage: 1000 mcg per lozenge
  • Original cherry flavor

Disadvantages

  • No adenosylcobalamin
  • No B6 and folic acid

This product is available at bol.com, among others.

The Vitals lozenges are in third place in my top 3 because they contain a good dose of methylcobalamin, one of the two most absorbable forms of vitamin B12. However, it's a shame there aren't any added fortifying vitamins.

1. The best forms of vitamin B12 in tablets

Vitamin B12 comes in different forms, but not all forms are absorbed equally well by your body.

The best vitamin B12 tablets contain the active and natural forms :

  • Methylcobalamin – highly effective, immediately absorbable and important for supporting the nervous system.
  • Adenosylcobalamin – also directly absorbable and essential for the conversion of fatty acids and amino acids into energy.

These forms can be used directly by your body, making them work faster and more efficiently.

There are two other, synthetic forms of vitamin B12.

These are less active and must be converted in the body to methylcobalamin or adenosylcobalamin (the active forms) before they can be used:

  • Cyanocobalamin – often used because it is cheap and stable, but your body has a harder time absorbing it.
  • Hydroxocobalamin – Mainly used in injections because of its longer lasting effect, but less suitable in supplements.

Summary: Choose methylcobalamin or adenosylcobalamin for best results, as your body can use these forms directly.

2. Why are B12 melt tablets better than regular B12 tablets?

A melt tablet or sublingual tablet has several advantages over regular B12 tablets.

  1. When you place B12 melt tablets under your tongue, they dissolve slowly and are absorbed directly into your bloodstream through the mucous membranes of your mouth. This way, B12 bypasses digestion, making it more readily available to the body. (1) (2)
    This is especially useful for people who have difficulty absorbing nutrients through the intestines.

  2. In addition, it is ideal for people who have difficulty swallowing tablets, such as the elderly and children.

Summary: Buy a B12 supplement in the form of a melt tablet so that the B12 can be easily absorbed through your mouth.

3. Why vitamin B6 is necessary for better absorption

Vitamin B6 is important for the proper functioning of vitamin B12 in your body.

B12 must first be converted into an active form before it can work properly. Vitamin B6 helps with this conversion.

In addition, B6 and B12 work together to lower the amount of homocysteine ​​in your blood, which contributes to a healthy heart.

Without enough B6, B12 may be less effective, even if you are getting enough B12. .

Summary: B6 helps B12 do its job better by supporting conversion to active forms and working together in important processes.

4. Choose B12 tablets with only natural ingredients

Choose vitamin B12 melt tablets without artificial fragrances, flavors, or fillers. The manufacturer often indicates this on the packaging. Check the ingredients list.

Many B12 melt tablets contain synthetic additives to improve taste and texture, but these can reduce the effectiveness of the B12.

For best results, choose supplements with only natural ingredients like stevia or natural flavors. This way, you're guaranteed a safe and effective product.

5. What does vitamin B12 do?

Vitamin B12 plays a role in your energy metabolism and nervous system:

  • Helps reduce fatigue
  • Supports the nervous system and contributes to concentration and memory
  • Plays a role in the production of cells, including red blood cells
  • Supports the immune system and homocysteine ​​metabolism *

(*) Homocysteine ​​is a substance that occurs naturally in your body. Too much homocysteine ​​can be bad for your heart. Vitamin B12 helps convert homocysteine ​​into other substances, preventing excessive levels from remaining in your blood. This helps keep your heart healthy.

6. When do you need vitamin B12 tablets?

People who often suffer from vitamin B12 deficiency include:

  • Vegetarians and vegans - Because vitamin B12 is mainly found in animal products. (3)
  • Elderly - The body often has difficulty absorbing B12 as you age.
  • People with stomach or intestinal problems - Such as Crohn's disease or celiac disease, which can interfere with B12 absorption.
  • People taking certain medications – such as antacids or diabetes medications – that can affect B12 absorption.

7. The symptoms of a B12 deficiency

A vitamin B12 deficiency can cause anemia , which manifests itself in:

  • Fatigue
  • Dizziness
  • Heart palpitations
  • Tinnitus

You may also experience neurological complaints, such as:

  • Tingling in the fingers
  • Memory loss
  • Coordination problems
  • Muscle weakness in the legs

Good to know: Your body has a storehouse of B12. Because of this, it can take months or even a year before you notice you're not getting enough B12.

8. How much B12 do the best B12 tablets contain?

As an adult, you need 2.8 mcg of vitamin B12 daily .

But if you have a B12 deficiency, you need a higher dose so your body can replenish its reserves. That's why supplements contain a higher dose.

The best B12 tablets contain a safe and effective dose between 500 and 1000 micrograms. (4)

This is significantly more than the RDA, but is often recommended in case of a deficiency to achieve faster results.

Please note: The best dose for you depends on your individual situation and is best discussed with a doctor, especially if you suspect you have a deficiency.

9. Can you also take too much vitamin B12?

The risk of having too much vitamin B12 is very small. Your body only absorbs what it needs, and any excess is excreted in urine.

And because there are no known harmful effects from long-term high intake, no maximum safe amount has been established.

In general, vitamin B12 is well tolerated, and toxicity is rare.

10. Vitamin B12 injection or tablets?

If you have a vitamin B12 deficiency, it's usually wise to try melt tablets first. These tablets dissolve in your mouth and bypass the gastrointestinal tract, making them often effective, even if absorption is difficult.

Melting tablets are easy to use and have few risks.

Only if melting tablets are not effective enough or are not suitable should you consider B12 injections together with your doctor.

Injections are often a last resort because they are administered directly into the muscles and the vitamin becomes fully available.

This may be necessary in the following cases:

  • Stomach or intestinal problems , such as celiac disease or Crohn's disease
  • A lack of intrinsic factor , for example in pernicious anemia
  • Elderly people with reduced stomach acid production

In short: Start with melting tablets and consult your doctor if your symptoms persist. Injections are effective, but only necessary for severe deficiencies or specific medical conditions.

Ebrina van der Bijl - Natural Performance

Ebrina van der Bijl

Ebrina is a nutritionist with a deep commitment to healthy eating and a sustainable lifestyle, based in beautiful Portugal. Her passion for natural and organic products is at the heart of her work. With a background in Nutrition & Dietetics and experience in product development and writing, she translates complex scientific information into practical advice for a balanced lifestyle.

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Sources used:

  1. Bensky, M.J., Ayalon-Dangur, I., Ayalon-Dangur, R., Naamany, E., Gafter-Gvili, A., Koren, G., & Shiber, S. (2019). Comparison of sublingual vs. intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency. Drug Delivery And Translational Research , 9 (3), 625–630. https://doi.org/10.1007/s13346-018-00613-y
  2. Tuğba-Kartal, A., & Çağla-Mutlu, Z. (2020b). Comparison of Sublingual and Intramuscular Administration of Vitamin B12 for the Treatment of Vitamin B12 Deficiency in Children. Revista de Investigacion clinica , 72 (6). https://doi.org/10.24875/ric.20000208
  3. Niklewicz, A., Hannibal, L., Warren, M., & Ahmadi, K. R. (2024). A systematic review and meta‐analysis of functional vitamin B12 status among adult vegans. Nutrition Bulletin , 49 (4), 463–479. https://doi.org/10.1111/nbu.12712
  4. Del Bo, C., Riso, P., Gardana, C., Brusamolino, A., Battezzati, A., & Ciappellano, S. (2018). Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: A randomized controlled trial. Clinical Nutrition , 38 (2), 575–583. https://doi.org/10.1016/j.clnu.2018.02.008
  5. Abdelwahab, O.A., Abdelaziz, A., Diab, S., Khazragy, A., Elboraay, T., Fayad, T., Diab, R.A., & Negida, A. (2024). Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis. Irish Journal Of Medical Science (1971 -) , 193 (3), 1621–1639. https://doi.org/10.1007/s11845-023-03602-4